From Wet Lab to RL Env: 10,000 Drug-Discovery Campaigns in a Weekend — Ian Quigley, Leash Bio

From a four-billion-measurement Kaggle competition to models that recognize a molecule’s chemist, Leash Bio is testing what AI actually learns about chemistry. Co-founder and CEO Ian Quigley joins Brandon Anderson and RJ Honicky to explain how Leash makes DNA-encoded libraries (DELs) produce clean, reproducible protein–small-molecule binding data—and why collecting the right experiments matters as much as choosing a model. We go deep on hidden shortcuts in public datasets, Hermes’ comparison with Boltz, and the protein mutations that expose memorization. Ian explains how Leash’s measured chem